Structure of PDB 2dys Chain A

Receptor sequence

>2dysA (length=514) Species: 9913 (Bos taurus) [Search protein sequence]

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGD
DQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNM
SFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSL
HLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLP
VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPG
FGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTV
GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLF
SGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMW
NTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPP
PYHTFEEPTYVNLK

3D structure

PDB

2dys Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase

Chain

Resolution

2.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y19 V29 L33 I37 V58 H61 N80 D91 N98 S101 L105 W126 S156 S157 G160 T167 H240 E242 Y244 S255 G272 H290 H291 T316 K319 H376 F377 H378 R438 R439
Catalytic site (residue number reindexed from 1)	Y19 V29 L33 I37 V58 H61 N80 D91 N98 S101 L105 W126 S156 S157 G160 T167 H240 E242 Y244 S255 G272 H290 H291 T316 K319 H376 F377 H378 R438 R439
Enzyme Commision number	7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CU	A	H240 H290 H291	H240 H290 H291
BS02	MG	A	H368 D369	H368 D369
BS03	HEA	A	A24 G27 T31 S34 I37 R38 Y54 V58 H61 A62 M65 G125 W126 Y371 F377 H378 S382 V386 F393 F425 R438 R439 M468	A24 G27 T31 S34 I37 R38 Y54 V58 H61 A62 M65 G125 W126 Y371 F377 H378 S382 V386 F393 F425 R438 R439 M468
BS04	HEA	A	W126 W236 V243 Y244 I247 H290 H291 G317 T349 G352 G355 L358 A359 D364 H368 H376 F377 V380 L381 R438	W126 W236 V243 Y244 I247 H290 H291 G317 T349 G352 G355 L358 A359 D364 H368 H376 F377 V380 L381 R438
BS05	PGV	A	N406 T408 W409	N406 T408 W409
BS06	PGV	A	F94 R96 M97 M100 F148	F94 R96 M97 M100 F148
BS07	PSC	A	F321 H328	F321 H328
BS08	DCW	A	I158 P200	I158 P200
BS09	CDL	A	F282 D300 Y304 S307	F282 D300 Y304 S307

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0045277	respiratory chain complex IV

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2dys, PDBe:2dys, PDBj:2dys
PDBsum	2dys
PubMed	17332748
UniProt	P00396\|COX1_BOVIN Cytochrome c oxidase subunit 1 (Gene Name=MT-CO1)

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