Structure of PDB 2dwc Chain A

Receptor sequence
>2dwcA (length=406) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
VVMIKLRDELGTATTDSAQKILLLGSGELGKEIAIEAQRLGVEVVAVDRY
ANAPAMQVAHRSYVGNMMDKDFLWSVVEREKPDAIIPEIEAINLDALFEF
EKDGYFVVPNARATWIAMHRERLRETLVKEAKVPTSRYMYATTLDELYEA
CEKIGYPCHTKAIMSYFVKGPEDIPKAWEEEKIIVEEHIDFDVEVTELAV
RHFDENGEIVTTFPKPVGHYQIDGDYHASWQPAEISEKAEREVYRIAKRI
TDVLGGLGIFGVEMFVKGDKVWANEVSPRPHDTGMVTLASHPPGFSEFAL
HLRAVLGLPIPGEWVDGYRLFPMLIPAATHVIKAKVSGYSPRFRGLVKAL
SVPNATVRLFGKPEAYVGRRLGIALAWDKDVEVAKRKAEMVAHMIELRTR
SSDWHD
3D structure
PDB2dwc Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E279 E291 D298 T299 R386
Catalytic site (residue number reindexed from 1) E263 E275 D282 T283 R370
Enzyme Commision number 6.3.1.21: phosphoribosylglycinamide formyltransferase 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R121 H160 K162 H204 I205 F207 E210 Q237 F281 N290 E291 R120 H159 K161 H188 I189 F191 E194 Q221 F265 N274 E275
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004644 phosphoribosylglycinamide formyltransferase activity
GO:0005524 ATP binding
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
GO:0016874 ligase activity
GO:0043815 phosphoribosylglycinamide formyltransferase 2 activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009152 purine ribonucleotide biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2dwc, PDBe:2dwc, PDBj:2dwc
PDBsum2dwc
PubMed
UniProtO58056|PURT_PYRHO Formate-dependent phosphoribosylglycinamide formyltransferase (Gene Name=purT)

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