Structure of PDB 2dw4 Chain A

Receptor sequence
>2dw4A (length=634) Species: 9606 (Homo sapiens) [Search protein sequence]
SGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLW
LDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIK
PLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFR
KGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVP
KEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEK
HVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHTAEFLVKSKHRD
LTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANL
EFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKL
NTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPA
VQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTA
SRGELFLFWNLAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSS
AVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPPIPRLF
FAGEHTIRNYPATVHGALLSGLREAGRIADQFLG
3D structure
PDB2dw4 Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T335 D553 K661
Catalytic site (residue number reindexed from 1) T164 D367 K475
Enzyme Commision number 1.14.99.66: [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G285 G287 S289 E308 A309 R310 G315 R316 G330 A331 M332 V333 V590 L625 W751 W756 S760 Y761 G800 E801 T810 V811 A814 G114 G116 S118 E137 A138 R139 G144 R145 G159 A160 M161 V162 V404 L439 W563 W568 S572 Y573 G603 E604 T613 V614 A617
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2dw4, PDBe:2dw4, PDBj:2dw4
PDBsum2dw4
PubMed18039463
UniProtO60341|KDM1A_HUMAN Lysine-specific histone demethylase 1A (Gene Name=KDM1A)

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