Structure of PDB 2dw2 Chain A

Receptor sequence
>2dw2A (length=415) Species: 8730 (Crotalus atrox) [Search protein sequence]
NPFRFVELVLVVDKAMVTKNNGDLDKIKTRMYEIVNTVNEIYRYMYIHVA
LVGLEIWSNEDKITVKPEAGYTLNAFGEWRKTDLLTRKKHDNAQLLTAID
LDRVIGLAYVGSMCHPKRSTGIIQDYSEINLVVAVIMAHEMGHNLGINHD
SGYCSCGDYACIMRPEISPEPSTFFSNCSYFECWDFIMNHNPECILNEPL
GTDIISPPVCGNELLEVGEECDCGTPENCQNECCDAATCKLKSGSQCGHG
DCCEQCKFSKSGTECRASMSECDPAEHCTGQSSECPADVFHKNGQPCLDN
YGYCYNGNCPIMYHQCYDLFGADVYEAEDSCFERNQKGNYYGYCRKENGN
KIPCAPEDVKCGRLYCKDNSPGQNNPCKMFYSNEDEHKGMVLPGTKCADG
KVCSNGHCVDVATAY
3D structure
PDB2dw2 Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins
ChainA
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A S464 E465 S270 E271
BS02 ZN A H333 H337 H343 H139 H143 H149
BS03 CA A E201 D285 C388 N391 E7 D91 C194 N197
BS04 CA A V403 N406 L408 E410 E413 D416 V209 N212 L214 E216 E219 D222
BS05 CA A D467 P468 E470 D482 V483 D273 P274 E276 D288 V289
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2dw2, PDBe:2dw2, PDBj:2dw2
PDBsum2dw2
PubMed17485084
UniProtQ90282|VM3VB_CROAT Zinc metalloproteinase-disintegrin-like VAP2B

[Back to BioLiP]