Structure of PDB 2dw1 Chain A

Receptor sequence

>2dw1A (length=415) Species: 8730 (Crotalus atrox)

NPFRFVELVLVVDKAMVTKNNGDLDKIKTRMYEIVNTVNEIYRYMYIHVA
LVGLEIWSNEDKITVKPEAGYTLNAFGEWRKTDLLTRKKHDNAQLLTAID
LDRVIGLAYVGSMCHPKRSTGIIQDYSEINLVVAVIMAHEMGHNLGINHD
SGYCSCGDYACIMRPEISPEPSTFFSNCSYFECWDFIMNHNPECILNEPL
GTDIISPPVCGNELLEVGEECDCGTPENCQNECCDAATCKLKSGSQCGHG
DCCEQCKFSKSGTECRASMSECDPAEHCTGQSSECPADVFHKNGQPCLDN
YGYCYNGNCPIMYHQCYDLFGADVYEAEDSCFERNQKGNYYGYCRKENGN
KIPCAPEDVKCGRLYCKDNSPGQNNPCKMFYSNEDEHKGMVLPGTKCADG
KVCSNGHCVDVATAY

3D structure

• PDB: 2dw1 Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E201 D285 C388 N391	E7 D91 C194 N197
BS02	CA	A	V403 C404 N406 L408 E410 E413 D416	V209 C210 N212 L214 E216 E219 D222
BS03	CA	A	D467 P468 E470 D482 V483	D273 P274 E276 D288 V289
BS04	ZN	A	H333 H337 H343	H139 H143 H149
BS05	GM6	A	V298 I299 G300 I330 H333 E334 H337 H343 P359 E360 I361	V104 I105 G106 I136 H139 E140 H143 H149 P165 E166 I167

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:2dw1, PDBe:2dw1, PDBj:2dw1
• PDBsum: 2dw1
• PubMed: 17485084
• UniProt: Q90282|VM3VB_CROAT Zinc metalloproteinase-disintegrin-like VAP2B