Structure of PDB 2dvo Chain A

Receptor sequence
>2dvoA (length=185) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
MKIFFITSNPGKVREVANFLGTFGIEIVQLKHEYPEIQAEKLEDVVDFGI
SWLKGKVPEPFMIEDSGLFIESLKGFPGVYSSYVYRTIGLEGILKLMEGA
EDRRAYFKSVIGFYIDGKAYKFSGVTWGRISNEKRGTHGFGYDPIFIPEG
SEKTFAEMTIEEKNALSHRGKALKAFFEWLKVNLK
3D structure
PDB2dvo Structures of dimeric nonstandard nucleotide triphosphate pyrophosphatase from Pyrococcus horikoshii OT3: functional significance of interprotomer conformational changes
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.66: XTP/dITP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ITT A T7 S8 N9 K12 E36 D65 S66 S81 S82 F107 F140 Y142 D143 K163 H168 R169 T7 S8 N9 K12 E36 D65 S66 S81 S82 F107 F140 Y142 D143 K163 H168 R169
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016787 hydrolase activity
GO:0017111 ribonucleoside triphosphate phosphatase activity
GO:0035870 dITP diphosphatase activity
GO:0036220 ITP diphosphatase activity
GO:0036222 XTP diphosphatase activity
GO:0046872 metal ion binding
GO:0047429 nucleoside triphosphate diphosphatase activity
Biological Process
GO:0009117 nucleotide metabolic process
GO:0009143 nucleoside triphosphate catabolic process
GO:0009146 purine nucleoside triphosphate catabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2dvo, PDBe:2dvo, PDBj:2dvo
PDBsum2dvo
PubMed18062990
UniProtO59580|IXTPA_PYRHO dITP/XTP pyrophosphatase (Gene Name=PH1917)

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