Structure of PDB 2dij Chain A

Receptor sequence

>2dijA (length=686) Species: 1397 (Niallia circulans) [Search protein sequence]

APDTSVSNKQNFSTDVIYQIFTDRFSDGNPANNPTGAAFDGTCTNLRLYC
GGDWQGIINKINDGYLTGMGVTAIWISQPVENIYSIINYSGVNNTAYHGY
WARDFKKTNPAYGTIADFQNLIAAAHAKNIKVIIDFAPNHTSPASSDQPS
FAENGRLYDNGTLLGGYTNDTQNLFHHNGGTDFSTTENGIYKNLFDLADL
NHNNSTVDVYLKDAIKMWLDLGIDGIRMDAVKHMPFGWQKSFMAAVNNYK
PVFTFGEWFLGVNEVSPENHKFANESGMSLLDFRFAQKVRQVFRDNTDNM
YGLKAMLEGSAADYAQVDDQVTFIDNHDMERFHASNANRRKLEQALAFTL
TSRGVPAIYYGTEQYMSGGTDPDNRARIPSFSTSTTAYQVIQKLAPLRKC
NPAIAYGSTQERWINNDVLIYERKFGSNVAVVAVNRNLNAPASISGLVTS
LPQGSYNDVLGGLLNGNTLSVGSGGAASNFTLAAGGTAVWQYTAATATPT
IGHVGPMMAKPGVTITIDGRGFGSSKGTVYFGTTAVSGADITSWEDTQIK
VKIPAVAGGNYNIKVANAAGTASNVYDNFEVLSGDQVSVRFVVNNATTAL
GQNVYLTGSVSELGNWDPAKAIGPMYNQVVYQYPNWYYDVSVPAGKTIEF
KFLKKQGSTVTWEGGSNHTFTAPSSGTATINVNWQP

3D structure

PDB

2dij Structure of cyclodextrin glycosyltransferase complexed with a maltononaose inhibitor at 2.6 angstrom resolution. Implications for product specificity.

Chain

Resolution

2.6 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D135 R227 D229 E257 H327 D328
Catalytic site (residue number reindexed from 1)	D135 R227 D229 E257 H327 D328
Enzyme Commision number	2.4.1.19: cyclomaltodextrin glucanotransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	W413 I414	W413 I414
BS02	GLC	A	E411 R412 G446	E411 R412 G446
BS03	GLC	A	K651 W662	K651 W662
BS04	GLC	A	W616 W662 N667	W616 W662 N667
BS05	GLC	A	T598 A599 Y633	T598 A599 Y633
BS06	GLC	A	L600 G601 Q602 N603 N627	L600 G601 Q602 N603 N627
BS07	GLC	A	F183 K232	F183 K232
BS08	G6D	A	A230 H233 E257 D328	A230 H233 E257 D328
BS09	GLC	A	Y100 W101 L197 D371 R375	Y100 W101 L197 D371 R375
BS10	GLC	A	Y89 D196	Y89 D196
BS11	GLC	A	G180 N193 F195	G180 N193 F195
BS12	GLC	A	S145 S146 D147	S145 S146 D147
BS13	CA	A	D27 N29 P30 N32 N33 G51 D53	D27 N29 P30 N32 N33 G51 D53
BS14	CA	A	N139 I190 D199 H233	N139 I190 D199 H233
BS15	ADH	A	Y100 H140 D229 E257 H327 D328	Y100 H140 D229 E257 H327 D328

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004556	alpha-amylase activity
GO:0016757	glycosyltransferase activity
GO:0030246	carbohydrate binding
GO:0043169	cation binding
GO:0043895	cyclomaltodextrin glucanotransferase activity
GO:0046872	metal ion binding
GO:2001070	starch binding

	Biological Process
GO:0005975	carbohydrate metabolic process

	Cellular Component
GO:0005576	extracellular region

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2dij, PDBe:2dij, PDBj:2dij
PDBsum	2dij
PubMed	8672460
UniProt	P43379\|CDGT2_NIACI Cyclomaltodextrin glucanotransferase (Gene Name=cgt)

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