Structure of PDB 2ddy Chain A

Receptor sequence
>2ddyA (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHF
RKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDE
DERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNF
KLSQDDIKGIQKLYGKRSNSRKK
3D structure
PDB2ddy Solution Structure of Matrilysin (MMP-7) Complexed to Constraint Conformational Sulfonamide Inhibitor
ChainA
ResolutionN/A
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H120 E121 H124 H130
Catalytic site (residue number reindexed from 1) H120 E121 H124 H130
Enzyme Commision number 3.4.24.23: matrilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D76 G77 G79 T81 D99 E102 D76 G77 G79 T81 D99 E102
BS02 CA A D59 G91 L92 G93 D95 D59 G91 L92 G93 D95
BS03 ZN A H69 D71 H84 H97 H69 D71 H84 H97
BS04 ZN A H120 H124 H130 H120 H124 H130
BS05 MDW A T81 L82 A83 A117 H120 E121 H124 H130 Y142 T81 L82 A83 A117 H120 E121 H124 H130 Y142 BindingDB: IC50=3162nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Cellular Component
External links
PDB RCSB:2ddy, PDBe:2ddy, PDBj:2ddy
PDBsum2ddy
PubMed
UniProtP09237|MMP7_HUMAN Matrilysin (Gene Name=MMP7)

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