Structure of PDB 2ddf Chain A

Receptor sequence
>2ddfA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAW
DNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKML
LEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPHGGVCPKAYYS
PVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLA
ECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQ
ERS
3D structure
PDB2ddf Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H405 H409 H415 H184 H188 H194
BS02 CA A D342 F343 G346 N389 D125 F126 G129 N168
BS03 INN A G346 T347 Y390 H405 E406 H409 H415 P437 I438 A439 G129 T130 Y169 H184 E185 H188 H194 P216 I217 A218 MOAD: ic50=41nM
PDBbind-CN: -logKd/Ki=7.39,IC50=41nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2ddf, PDBe:2ddf, PDBj:2ddf
PDBsum2ddf
PubMed16459338
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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