Structure of PDB 2dcu Chain A

Receptor sequence
>2dcuA (length=407) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
KTRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFAD
AEIRRCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGA
SLMDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEK
ALENYRQIKEFIKGTVAENAPIIPISALHGANIDVLVKAIEEFIPTPKRD
SNKPPKMLVLRSFDVNKPGTPPEKLVGGVLDGSIVQGKLKVGDEIEIRPG
VPYEEHGRIKYEPITTEIVSLQAGGQFVEEAYPGGLVGIGTKLDPYLTKG
DLMAGNVVGKPGKLPPVWTDLRLEVHLLERVVGTEQELNVEPIKRKEVLL
LNVGTARTMGLVTALGKDEIELKLQIPVCAEPGERVAISRQIGSRWRLIG
YGIIKEL
3D structure
PDB2dcu Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region.
ChainA
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D21 K24 T25 T48 H94
Catalytic site (residue number reindexed from 1) D16 K19 T20 T43 H89
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T25 P92 T20 P87
BS02 ZN A C61 C64 C73 C76 C56 C59 C68 C71
BS03 GDP A V20 D21 G23 K24 T25 T26 N146 E149 S181 A182 L183 V15 D16 G18 K19 T20 T21 N141 E144 S176 A177 L178
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2dcu, PDBe:2dcu, PDBj:2dcu
PDBsum2dcu
PubMed16924118
UniProtQ8U082|IF2G_PYRFU Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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