Structure of PDB 2d5c Chain A

Receptor sequence
>2d5cA (length=261) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MLRFAVLGHPVAHSLSPAMHAFALESLGLEGSYEAWDTPLEALPGRLKEV
RRAFRGVNLTLPLKEAALAHLDWVSPEAQRIGAVNTVLQVEGRLFGFNTD
APGFLEALKAGGIPLKGPALVLGAGGAGRAVAFALREAGLEVWVWNRTPQ
RALALAEEFGLRAVPLEKAREARLLVNATRVGLEDPSASPLPAELFPEEG
AAVDLVYRPLWTRFLREAKAKGLKVQTGLPMLAWQGALAFRLWTGLLPDP
SGMEEAARRAL
3D structure
PDB2d5c Crystal Structures of Shikimate Dehydrogenase AroE from Thermus thermophilus HB8 and its Cofactor and Substrate Complexes: Insights into the Enzymatic Mechanism
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K64 D100
Catalytic site (residue number reindexed from 1) K64 D100
Enzyme Commision number 1.1.1.25: shikimate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SKM A S14 S16 N58 K64 N85 D100 Q235 S14 S16 N58 K64 N85 D100 Q235
Gene Ontology
Molecular Function
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0019632 shikimate metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2d5c, PDBe:2d5c, PDBj:2d5c
PDBsum2d5c
PubMed17825835
UniProtQ5SJF8|AROE_THET8 Shikimate dehydrogenase (NADP(+)) (Gene Name=aroE)

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