Structure of PDB 2d4h Chain A

Receptor sequence
>2d4hA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
IHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYL
MNKLAGKKKGFSLGSTVQKGIWMWCVPHPKKPGHILVLLDTEGLGDVENQ
NDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDE
SADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDE
TFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVA
DFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAV
3D structure
PDB2d4h How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP A R48 T49 G50 K51 S52 F65 S66 R183 D184 P241 R44 T45 G46 K47 S48 F61 S62 R166 D167 P224
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2d4h, PDBe:2d4h, PDBj:2d4h
PDBsum2d4h
PubMed16511497
UniProtP32455|GBP1_HUMAN Guanylate-binding protein 1 (Gene Name=GBP1)

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