Structure of PDB 2d1s Chain A

Receptor sequence
>2d1sA (length=539) Species: 7051 (Nipponoluciola cruciata) [Search protein sequence]
DENIVVGPKPFYPIEEGSAGTQLRKYMERYAKLGAIAFTNAVTGVDYSYA
EYLEKSCCLGKALQNYGLVVDGRIALCSENCEEFFIPVIAGLFIGVGVAP
TNEIYTLRELVHSLGISKPTIVFSSKKGLDKVITVQKTVTTIKTIVILDS
KVDYRGYQCLDTFIKRNTPPGFQASSFKTVEVDRKEQVALIMNSSGSTGL
PKGVQLTHENIVTRFSHARDPIYGNQVSPGTAVLTVVPFHHGFGMFTTLG
YLICGFRVVMLTKFDEETFLKTLQDYKCTSVILVPTLFAILNKSELLNKY
DLSNLVEIASGGAPLSKEVGEAVARRFNLPGVRQGYGLTETTSAIIITPE
GDDKPGASGKVVPLFKAKVIDLDTKKSLGPNRRGEVCVKGPMLMKGYVNN
PEATKELIDEEGWLHTGDIGYYDEEKHFFIVDRLKSLIKYKGYQVPPAEL
ESVLLQHPSIFDAGVAGVPDPVAGELPGAVVVLESGKNMTEKEVMDYVAS
QVSNAKRLRGGVRFVDEVPKGLTGKIDGRAIREILKKPV
3D structure
PDB2d1s Structural basis for the spectral difference in luciferase bioluminescence.
ChainA
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S200 R220 H247 T345 E346 K445 Q450 K531
Catalytic site (residue number reindexed from 1) S194 R214 H241 T339 E340 K439 Q444 K525
Enzyme Commision number 1.13.12.7: firefly luciferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLU A S200 S201 H247 F249 T253 I288 G318 A319 P320 Q340 G341 Y342 G343 L344 T345 S349 A350 D424 R439 K531 S194 S195 H241 F243 T247 I282 G312 A313 P314 Q334 G335 Y336 G337 L338 T339 S343 A344 D418 R433 K525
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0004497 monooxygenase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0047077 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0008218 bioluminescence
GO:0046949 fatty-acyl-CoA biosynthetic process
Cellular Component
GO:0005777 peroxisome

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Biological Process
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Cellular Component
External links
PDB RCSB:2d1s, PDBe:2d1s, PDBj:2d1s
PDBsum2d1s
PubMed16541080
UniProtP13129|LUCI_NIPCR Luciferin 4-monooxygenase

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