Structure of PDB 2d1c Chain A

Receptor sequence
>2d1cA (length=495) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PLITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAY
EVREAGASVFRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANV
TLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQ
TPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGT
LKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILS
DLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSA
VMMLRYLEEFATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAI
IQNLGKTPRKTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNLL
PEALGKALEDLAAGTPFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYT
GEGEAKDPEILDLVSRVASRFRWMHLEKLQEFDGEPGFTKAQGED
3D structure
PDB2d1c Crystal Structure Of TT0538 protein from Thermus thermophilus HB8
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y144 K191 D224 D248 D252
Catalytic site (residue number reindexed from 1) Y143 K190 D223 D247 D251
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A P87 L88 E89 T90 N100 L261 G262 H280 G281 S282 A283 K285 Y286 I292 N293 D334 P86 L87 E88 T89 N99 L260 G261 H279 G280 S281 A282 K284 Y285 I291 N292 D333
BS02 NAP A I222 N225 Q229 I221 N224 Q228
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2d1c, PDBe:2d1c, PDBj:2d1c
PDBsum2d1c
PubMed
UniProtP33197|IDH_THET8 Isocitrate dehydrogenase [NADP] (Gene Name=icd)

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