Structure of PDB 2czc Chain A

Receptor sequence
>2czcA (length=334) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MKVKVGVNGYGTIGKRVAYAVTKQDDMELIGITKTKPDFEAYRAKELGIP
VYAASEEFIPRFEKEGFEVAGTLNDLLEKVDIIVDATPGGIGAKNKPLYE
KAGVKAIFQGGEKADVAEVSFVAQANYEAALGKNYVRVVSCNTTGLVRTL
SAIREYADYVYAVMIRRAADPNDTKRGPINAIKPTVEVPSHHGPDVQTVI
PINIETMAFVVPTTLMHVHSVMVELKKPLTKDDVIDIFENTTRVLLFEKE
KGFDSTAQIIEFARDLHREWNNLYEIAVWKESINIKGNRLFYIQAVHQES
DVIPENIDAIRAMFELADKWDSIKKTNKSLGILK
3D structure
PDB2czc Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Pyrococcus horikoshii OT3
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C141 H217
Catalytic site (residue number reindexed from 1) C141 H217
Enzyme Commision number 1.2.1.59: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A N8 G11 T12 I13 T35 A54 A86 T87 P88 Q109 G111 C141 R167 D170 Q298 N8 G11 T12 I13 T35 A54 A86 T87 P88 Q109 G111 C141 R167 D170 Q298
Gene Ontology
Molecular Function
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0043891 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
GO:0047100 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006096 glycolytic process
GO:0009089 lysine biosynthetic process via diaminopimelate
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:2czc, PDBe:2czc, PDBj:2czc
PDBsum2czc
PubMed
UniProtO59494|G3P_PYRHO Glyceraldehyde-3-phosphate dehydrogenase (Gene Name=gap)

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