Structure of PDB 2cww Chain A

Receptor sequence
>2cwwA (length=376) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MRIQVNAKGAARLLSRHLWVFRRDVVSGPETPGLYPVYWGRRFLALALYN
PHTDLAVRAYRFAPAEDPVAALLENLAQALARREAVLRQDPEGGYRLVHA
EGDLLPGLVVDYYAGHAVVQATAHAWEGLLPQVAEALRPHVQSVLAKNDA
RTRELEGLPLYVRPLLGEVPERVQVQEGRVRYLVDLGAYLDQRENRLYME
RFRGERALDVFSYAGGFALHLALGFREVVAVDSSAEALRRAEENARLNGL
GNVRVLEANAFDLLRRLEKEGERFDLVVLDPPAFAKGKKDVERAYRAYKE
VNLRAIKLLKEGGILATASCSHHMTEPLFYAMVAEAAQDAHRLLRVVEKR
GQPFDHPVLLNHPETHYLKFAVFQVL
3D structure
PDB2cww Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.191: 23S rRNA (cytosine(1962)-C(5))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y195 R202 F217 S218 Y219 D238 S239 N265 A266 D286 Y189 R196 F211 S212 Y213 D232 S233 N259 A260 D280
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2cww, PDBe:2cww, PDBj:2cww
PDBsum2cww
PubMed16511182
UniProtQ5SIT4|RLM_THET8 Ribosomal RNA large subunit methyltransferase I (Gene Name=TTHA1280)

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