Structure of PDB 2cvx Chain A

Receptor sequence
>2cvxA (length=664) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TLAARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVM
ENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVA
LGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKE
DSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPM
IRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRA
RDLFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYE
KEGRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSS
NLCCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAK
VVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDS
EEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMW
DQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVT
SNMYSFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKD
LYKTVWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGW
KKGLKTGMYYLRTQ
3D structure
PDB2cvx Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C143 N351 C353 E355 C368 Y659 Y660
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGT A D226 S227 I228 R256 I262 A263 G264 D151 S152 I153 R181 I187 A188 G189
BS02 ADP A A201 S202 S217 C218 G246 G247 Q288 R293 A296 L427 C428 E430 L445 T608 A609 S610 T611 A126 S127 S142 C143 G171 G172 Q213 R218 A221 L352 C353 E355 L370 T533 A534 S535 T536
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2cvx, PDBe:2cvx, PDBj:2cvx
PDBsum2cvx
PubMed16537479
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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