Structure of PDB 2cvw Chain A

Receptor sequence
>2cvwA (length=649) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRD
FQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALETY
NLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECAL
ISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGG
NKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMK
RVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWY
SILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDET
AVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYY
PVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIY
HASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRK
DIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSFQVVNPYLLR
DLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIIN
MAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQ
3D structure
PDB2cvw Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C128 N336 C338 E340 C353 Y644 Y645
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTP A D226 S227 I228 I231 R256 I262 A263 N270 D136 S137 I138 I141 R166 I172 A173 N180
BS02 GDP A S202 S217 C218 G246 G247 L427 C428 E430 L445 P607 T608 A609 T611 S112 S127 C128 G156 G157 L337 C338 E340 L355 P517 T518 A519 T521
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2cvw, PDBe:2cvw, PDBj:2cvw
PDBsum2cvw
PubMed16537479
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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