Structure of PDB 2cu0 Chain A

Receptor sequence
>2cu0A (length=358) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
KFVEKLEKAIKGYTFDDVLLIPQATEVEPKDVDVSTRITPNVKLNIPILS
AAMDTVTEWEMAVAMAREGGLGVIHRNMGIEEQVEQVKRVKRAEKYKNAV
RDENGELLVAAAVSPFDIKRAIELDKAGVDVIVVDTAHAHNLKAIKSMKE
MRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSICTTRIVAGVGVP
QITAVAMVADRAQEYGLYVIADGGIRYSGDIVKAIAAGADAVMLGNLLAG
TKEAPGKEVIINGRKYKQYRGMGSLGAMMKYMKTRKFVPEGVEGVVPYRG
TVSEVLYQLVGGLKAGMGYVGARNIRELKEKGEFVIITHAGIKESHPHDI
IITNEAPN
3D structure
PDB2cu0 Crystal structure of inosine-5'-monophosphate dehydrogenase from Pyrococcus horikoshii OT3
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XMP A M55 G298 S299 I300 C301 D334 G336 G357 N358 Y381 G383 M384 G385 E412 M53 G186 S187 I188 C189 D222 G224 G245 N246 Y269 G271 M272 G273 E290
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2cu0, PDBe:2cu0, PDBj:2cu0
PDBsum2cu0
PubMed
UniProtO58045|IMDH_PYRHO Inosine-5'-monophosphate dehydrogenase (Gene Name=guaB)

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