Structure of PDB 2cts Chain A

Receptor sequence

>2ctsA (length=437) Species: 9823 (Sus scrofa)

ASSTNLKDILADLIPKEQARIKTFRQQHGNTAVGQITVDMMYGGMRGMKG
LVYETSVLDPDEGIRFRGYSIPECQKMLPKAKGGEEPLPEGLFWLLVTGQ
IPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNS
ESNFARAYAEGIHRTKYWELIYEDCMDLIAKLPCVAAKIYRNLYREGSSI
GAIDSKLDWSHNFTNMLGYTDAQFTELMRLYLTIHSDHEGGNVSAHTSHL
VGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEK
LRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPHDPMFKLV
AQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVS
RALGVLAQLIWSRALGFPLERPKSMSTDGLIKLVDSK

3D structure

• PDB: 2cts Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 A resolution.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S244 H274 H320 R329 D375
• Catalytic site (residue number reindexed from 1): S244 H274 H320 R329 D375
• Enzyme Commision number: 2.3.3.1: citrate (Si)-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	A	R46 P272 A277 E280 V314 V315 P316 G317 Y318 A321 K366	R46 P272 A277 E280 V314 V315 P316 G317 Y318 A321 K366

Gene Ontology

Molecular Function

• GO:0004108 citrate (Si)-synthase activity
• GO:0016740 transferase activity
• GO:0036440 citrate synthase activity
• GO:0042802 identical protein binding
• GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006099 tricarboxylic acid cycle
• GO:0006101 citrate metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:2cts, PDBe:2cts, PDBj:2cts
• PDBsum: 2cts
• PubMed: 7120407
• UniProt: P00889|CISY_PIG Citrate synthase, mitochondrial (Gene Name=CS)