Structure of PDB 2crk Chain A

Receptor sequence

>2crkA (length=365) Species: 9986 (Oryctolagus cuniculus)

NKYKLNYKSEEEYPDLSKHNNHMAKVLTPDLYKKLRDKETPSGFTLDDVI
QTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFKPTDKHK
TDLNHENLKGGDDLDPHYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKL
SVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGM
ARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGL
QKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPK
FEEILTRLRLQKRGTSVFDISNADRLGSSEVEQVQLVVDGVKLMVEMEKK
LEKGQSIDDMIPAQK

3D structure

• PDB: 2crk Crystal structure of rabbit muscle creatine kinase.
• Chain: A
• Resolution: 2.35 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R132 E232 R236 C283 S285 R292 R320
• Catalytic site (residue number reindexed from 1): R125 E225 R229 C276 S278 R285 R313
• Enzyme Commision number: 2.7.3.2: creatine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SO4	A	R132 R320	R125 R313
BS02	SO4	A	R130 R132	R123 R125
BS03	SO4	A	R96 S285	R89 S278

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004111 creatine kinase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0016772 transferase activity, transferring phosphorus-containing groups

Biological Process

• GO:0009408 response to heat
• GO:0016310 phosphorylation
• GO:0046314 phosphocreatine biosynthetic process

Cellular Component

• GO:0005615 extracellular space

External links

• PDB: RCSB:2crk, PDBe:2crk, PDBj:2crk
• PDBsum: 2crk
• PubMed: 9849893
• UniProt: P00563|KCRM_RABIT Creatine kinase M-type (Gene Name=CKM)