Structure of PDB 2cpo Chain A

Receptor sequence

>2cpoA (length=299) Species: 5474 (Leptoxyphium fumago) [Search protein sequence]

QEPGSGIGYPYDNNTLPYVAPGPTDSRAPCPALNALANHGYIPHDGRAIS
RETLQNAFLNHMGIANSVIELALTNAFVVCEYVTGSDCGDSLVNLTLLAE
PHAFEHDHSFSRKDYKQGVANSNDFIDNRNFDAETFQTSLDVVAGKTHFD
YADMNEIRLQRESLSNELDFPGWFTESKPIQNVESGFIFALVSDFNLPDN
DENPLVRIDWWKYWFTNESFPYHLGWHPPSPAREIEFVTSASSAVLAASV
TSTPSSLPSGAIGPGAEAVPLSFASTMTPFLLATNAPYYAQDPTLGPND

3D structure

PDB

2cpo The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid.

Chain

Resolution

2.1 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	C29 H105 D106 E183
Catalytic site (residue number reindexed from 1)	C30 H106 D107 E184
Enzyme Commision number	1.11.1.10: chloride peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MAN	A	Y150 D200 E201 F236 S239	Y151 D201 E202 F237 S240
BS02	MAN	A	P178 S241 L245 G264 A265	P179 S242 L246 G265 A266
BS03	MAN	A	S242 A246	S243 A247
BS04	MAN	A	D152 T250	D153 T251
BS05	MAN	A	Q159 S251 P253	Q160 S252 P254
BS06	MAN	A	V249 T252	V250 T253
BS07	MN	A	E104 H105 S108	E105 H106 S109
BS08	HEM	A	C29 P30 A31 F57 A71 F103 E104 H105 S108 F109 S110 E183 F186	C30 P31 A32 F58 A72 F104 E105 H106 S109 F110 S111 E184 F187

Gene Ontology

	Molecular Function
GO:0004601	peroxidase activity

View graph for
Molecular Function

External links

PDB	RCSB:2cpo, PDBe:2cpo, PDBj:2cpo
PDBsum	2cpo
PubMed	8747463
UniProt	P04963\|PRXC_LEPFU Chloroperoxidase (Gene Name=CPO)

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