Structure of PDB 2cnv Chain A

Receptor sequence
>2cnvA (length=299) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIP
EKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQ
LEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKES
QEFPEPIFTPSTKDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAK
EKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQDS
YDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKWSH
3D structure
PDB2cnv X-Ray Diffraction Study of the Complex of the Enzyme Saicar Synthase with the Reaction Product
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A R73 H110 R72 H109
BS02 ASP A G184 E185 D186 L187 G177 E178 D179 L180
BS03 SSS A S40 A41 Y42 D43 I120 R122 S128 D215 T216 D239 R242 K260 R264 S39 A40 Y41 D42 I119 R121 S127 D208 T209 D232 R235 K253 R257
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2cnv, PDBe:2cnv, PDBj:2cnv
PDBsum2cnv
PubMed
UniProtP27616|PUR7_YEAST Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=ADE1)

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