Structure of PDB 2cnu Chain A

Receptor sequence
>2cnuA (length=302) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIP
EKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQ
LEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKES
QEFPEPIFTPSTKAEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKD
YAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGES
QDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKW
SH
3D structure
PDB2cnu Saicar Synthase: Substrate Recognition, Conformational Flexibility and Catalysis.
ChainA
Resolution1.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A S40 A41 Y42 D43 K260 R264 S39 A40 Y41 D42 K256 R260
BS02 ASP A G184 E185 D186 L187 G180 E181 D182 L183
BS03 ASP A R73 H110 R72 H109
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2cnu, PDBe:2cnu, PDBj:2cnu
PDBsum2cnu
PubMed
UniProtP27616|PUR7_YEAST Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=ADE1)

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