Structure of PDB 2cn5 Chain A

Receptor sequence
>2cn5A (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
HMSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRNVE
TEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKE
ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGH
SKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICL
SGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP
KARFTTEEALRHPWLQDEDMKRKFQDLLSEENE
3D structure
PDB2cn5 Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D347 K349 N352 D368 T387
Catalytic site (residue number reindexed from 1) D126 K128 N131 D147 T166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N352 D368 N131 D147
BS02 ADP A G227 S228 G229 C231 G232 V234 A247 K249 M304 E308 L354 D368 G20 S21 G22 C24 G25 V27 A40 K42 M83 E87 L133 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2cn5, PDBe:2cn5, PDBj:2cn5
PDBsum2cn5
PubMed16794575
UniProtO96017|CHK2_HUMAN Serine/threonine-protein kinase Chk2 (Gene Name=CHEK2)

[Back to BioLiP]