Structure of PDB 2cjx Chain A

Receptor sequence
>2cjxA (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]
SGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETF
RNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIF
GTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIET
3D structure
PDB2cjx Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T62 S63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1) T34 S35 H93 G94 C135 R136
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R64 H121 C163 R36 H93 C135
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2cjx, PDBe:2cjx, PDBj:2cjx
PDBsum2cjx
PubMed16787777
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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