Structure of PDB 2cje Chain A

Receptor sequence
>2cjeA (length=258) Species: 5664 (Leishmania major) [Search protein sequence]
NIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTELLDSYP
WKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPAASLKPL
KEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANAYRFDVI
IECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNNGVEDNS
LLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKDAERWFA
LAKENRLA
3D structure
PDB2cje The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUN A I28 E48 E51 D79 H82 F83 K179 N183 R186 Y191 K198 I21 E41 E44 D72 H75 F76 K172 N176 R179 Y184 K191
BS02 MG A E48 E51 E41 E44
BS03 MG A E48 E51 E76 D79 E41 E44 E69 D72
BS04 MG A E51 E76 E44 E69
Gene Ontology
Molecular Function
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005654 nucleoplasm

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:2cje, PDBe:2cje, PDBj:2cje
PDBsum2cje
PubMed21454646
UniProtO15826

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