Structure of PDB 2cj2 Chain A

Receptor sequence

>2cj2A (length=299) Species: 5474 (Leptoxyphium fumago)

EEPGSGIGYPYDNNTLPYVAPGPTDSRAPCPALNALANHGYIPHDGRAIS
RETLQNAFLNHMGIANSVIELALTNAFVVCEYVTGSDCGDSLVNLTLLAE
PHAFEHDHSFSRKDYKQGVANSNDFIDNRNFDAETFQTSLDVVAGKTHFD
YADMNEIRLQRESLSNELDFPGWFTESKPIQNVESGFIFALVSDFNLPDN
DENPLVRIDWWKYWFTNESFPYHLGWHPPSPAREIEFVTSASSAVLAASV
TSTPSSLPSGAIGPGAEAVPLSFASTMTPFLLATNAPYYAQDPTLGPND

3D structure

• PDB: 2cj2 Crystal Structures of Chloroperoxidase with its Bound Substrates and Complexed with Formate, Acetate, and Nitrate.
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C29 H105 D106 E183
• Catalytic site (residue number reindexed from 1): C30 H106 D107 E184
• Enzyme Commision number: 1.11.1.10: chloride peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	E104 H105 S108	E105 H106 S109
BS02	HEM	A	P28 C29 P30 A31 L32 F57 I63 A71 F103 E104 H105 S108 F109 S110 E183 F186 I187 W213	P29 C30 P31 A32 L33 F58 I64 A72 F104 E105 H106 S109 F110 S111 E184 F187 I188 W214
BS03	MAN	A	T238 E266	T239 E267
BS04	MAN	A	Y150 D200 E201 F236 S239	Y151 D201 E202 F237 S240
BS05	MAN	A	P178 N181 V182 S241 L245 G264 A265	P179 N182 V183 S242 L246 G265 A266
BS06	MAN	A	S239 S242	S240 S243
BS07	MAN	A	D152 E155 T250	D153 E156 T251
BS08	MAN	A	V141 Q159 S251 P253	V142 Q160 S252 P254
BS09	MAN	A	V249 T252 I261	V250 T253 I262

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity

External links

• PDB: RCSB:2cj2, PDBe:2cj2, PDBj:2cj2
• PDBsum: 2cj2
• PubMed: 16790441
• UniProt: P04963|PRXC_LEPFU Chloroperoxidase (Gene Name=CPO)