Structure of PDB 2ci7 Chain A

Receptor sequence
>2ci7A (length=273) Species: 9913 (Bos taurus) [Search protein sequence]
TFGRATHVVVRALPESLAQQALRRTKGDEVDFARAERQHQLYVGVLGSKL
GLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEADMMKEA
LEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTF
KDYAVSTVPVVDALHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHR
YDKLTVPDDTAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHMLI
PVSNSELEKVDGLLTCSSVLINK
3D structure
PDB2ci7 Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inhibitors.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.18: dimethylargininase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY A L29 D72 F75 R144 V267 L22 D65 F68 R137 V260
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016403 dimethylargininase activity
GO:0016597 amino acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000052 citrulline metabolic process
GO:0006525 arginine metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0017014 protein nitrosylation
GO:0045429 positive regulation of nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2ci7, PDBe:2ci7, PDBj:2ci7
PDBsum2ci7
PubMed16698551
UniProtP56965|DDAH1_BOVIN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (Gene Name=DDAH1)

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