Structure of PDB 2cgp Chain A

Receptor sequence
>2cgpA (length=200) Species: 562 (Escherichia coli) [Search protein sequence]
DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGK
EMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQ
VNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAM
THPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG
3D structure
PDB2cgp The structure of a CAP-DNA complex having two cAMP molecules bound to each monomer.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K57 S179 E181 R185 K50 S172 E174 R178
BS02 dna A T168 R169 Q170 R180 R185 K201 T161 R162 Q163 R173 R178 K194
BS03 CMP A V49 S62 I70 G71 E72 L73 R82 S83 R123 V42 S55 I63 G64 E65 L66 R75 S76 R116
BS04 CMP A K57 E58 Q170 G173 Q174 G177 C178 R180 K50 E51 Q163 G166 Q167 G170 C171 R173
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0030552 cAMP binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0045013 carbon catabolite repression of transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol
GO:0032993 protein-DNA complex

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Cellular Component
External links
PDB RCSB:2cgp, PDBe:2cgp, PDBj:2cgp
PDBsum2cgp
PubMed9096308
UniProtP0ACJ8|CRP_ECOLI DNA-binding transcriptional dual regulator CRP (Gene Name=crp)

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