Structure of PDB 2cfm Chain A

Receptor sequence
>2cfmA (length=561) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
MRYLELAQLYQKLEKTTMKLIKTRLVADFLKKVPDDHLEFIPYLILGEVF
PEWDERELGVGEKLLIKAVAMATGIDAKEIEESVKDTGDLGESIALAVKK
KKQKSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKVKYLADLFMDAEPLE
AKYLARTILGTMRTGVAEGLLRDAIAMAFHVKVELVERAYMLTSDFGYVA
KIAKLEGNEGLAKVQVQLGKPIKPMLAQQAASIRDALLEMGGEAEFEIKY
DGARVQVHKDGSKIIVYSRRLENVTRAIPEIVEALKEAIIPEKAIVEGEL
VAIGENGRPLPFQYVLRRFRRKHNIEEMMEKIPLELNLFDVLYVDGQSLI
DTKFIDRRRTLEEIIKQNEKIKVAENLITKKVEEAEAFYKRALEMGHEGL
MAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLFGSFI
LGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKRVWLQPK
VVIEVTYQEIQKSPKYRSGFALRFPRFVALRDDKGPEDADTIERIAQLYE
LQEKMKGKVES
3D structure
PDB2cfm The Closed Structure of an Archaeal DNA Ligase from Pyrococcus Furiosus.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A L226 A227 E247 K249 Y250 R254 R269 E299 F339 M401 K403 K420 L226 A227 E247 K249 Y250 R254 R269 E299 F339 M401 K403 K420
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051301 cell division
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2cfm, PDBe:2cfm, PDBj:2cfm
PDBsum2cfm
PubMed16820169
UniProtP56709|DNLI_PYRFU DNA ligase (Gene Name=lig)

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