Structure of PDB 2cfc Chain A

Receptor sequence
>2cfcA (length=250) Species: 78245 (Xanthobacter autotrophicus Py2) [Search protein sequence]
MSRVAIVTGASSGNGLAIATRFLARGDRVAALDLSAETLEETARTHWHAY
ADKVLRVRADVADEGDVNAAIAATMEQFGAIDVLVNNAGITGNSEAGVLH
TTPVEQFDKVMAVNVRGIFLGCRAVLPHMLLQGAGVIVNIASVASLVAFP
GRSAYTTSKGAVLQLTKSVAVDYAGSGIRCNAVCPGMIETPMTQWRLDQP
ELRDQVLARIPQKEIGTAAQVADAVMFLAGEDATYVNGAALVMDGAYTAI
3D structure
PDB2cfc Structural Basis for Stereoselectivity in the (R)-and (S)-Hydroxypropylthioethanesulfonate Dehydrogenases.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G13 S142 Y155 K159
Catalytic site (residue number reindexed from 1) G13 S142 Y155 K159
Enzyme Commision number 1.1.1.268: 2-(R)-hydroxypropyl-CoM dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G9 S12 G13 N14 D33 L34 A59 D60 V61 N87 A88 G89 I140 P185 G186 M187 I188 T190 P191 M192 T193 G9 S12 G13 N14 D33 L34 A59 D60 V61 N87 A88 G89 I140 P185 G186 M187 I188 T190 P191 M192 T193
BS02 KPC A F149 R152 Y155 W195 R196 F149 R152 Y155 W195 R196
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0050574 2-(R)-hydroxypropyl-CoM dehydrogenase activity
Biological Process
GO:0042208 propylene catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2cfc, PDBe:2cfc, PDBj:2cfc
PDBsum2cfc
PubMed16846226
UniProtQ56840|HCDR1_XANP2 2-(R)-hydroxypropyl-CoM dehydrogenase (Gene Name=xecD1)

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