Structure of PDB 2cfa Chain A

Receptor sequence
>2cfaA (length=180) Species: 10506 (Paramecium bursaria Chlorella virus 1) [Search protein sequence]
MSAKLISVTKPVVEGVNTAEELIAYAARVSNPENQKTASGLLKYCIRHKH
WSIFETAFMTLELKTSRGIAAQVLRHRSFHFQEFSQTWWATEQEKLYAQS
MELYNKALEKGIAKECARFILPLSTPTTIYMSGTIRDWIHYIELRTSNGT
QREHIDLANACKEIFIKEFPSIAKALDWVH
3D structure
PDB2cfa Catalytic Mechanism and Structure of Viral Flavin-Dependent Thymidylate Synthase Thyx.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A W54 R78 H79 S81 R173 D174 H177 W51 R75 H76 S78 R136 D137 H140
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2cfa, PDBe:2cfa, PDBj:2cfa
PDBsum2cfa
PubMed16707489
UniProtO41156|THYX_PBCV1 Probable flavin-dependent thymidylate synthase (Gene Name=A674R)

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