Structure of PDB 2cdz Chain A

Receptor sequence
>2cdzA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRGKLVAVK
KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH
DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS
LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLD
RLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT
3D structure
PDB2cdz Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D140 K142 D144 S145 D158 K167 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 23D A I327 E329 V335 M395 F397 L398 E399 G401 L447 I29 E31 V37 M95 F97 L98 E99 G101 L147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2cdz, PDBe:2cdz, PDBj:2cdz
PDBsum2cdz
PubMed17292838
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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