Structure of PDB 2cdb Chain A

Receptor sequence
>2cdbA (length=360) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
MKAIIVKPPNAGVQVKDVDEKKLDSYGKIKIRTIYNGICGADREIVNGKL
KGKDFLVLGHEAIGVVEESYHGFSQGDLVMPVNRRGCGICRNCLVGRPDF
CETGEFGEAGIHKMDGFMREWWYDDPKYLVKIPKSIEDIGILAQPLADIE
KSIEEILEVQKRVPVWTCDDGTLNCRKVLVVGTGPIGVLFTLLFRTYGLE
VWMANRREPTEVEQTVIEETKTNYYNSSNGYDKLKDSVGKFDVIIDATGA
DVNILGNVIPLLGRNGVLGLFGFSTSGSVPLDYKTLQEIVHTNKTIIGLV
NGQKPHFQQAVVHLASWKTLYPKAAKMLITKTVSINDEKELLKVLREKEH
GEIKIRILWE
3D structure
PDB2cdb The Structural Basis of Substrate Promiscuity in Glucose Dehydrogenase from the Hyperthermophilic Archaeon Sulfolobus Solfataricus.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.120: galactose 1-dehydrogenase (NADP(+)).
1.1.1.359: aldose 1-dehydrogenase [NAD(P)(+)].
1.1.1.47: glucose 1-dehydrogenase [NAD(P)(+)].
1.1.1.48: D-galactose 1-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A E114 Q150 D154 F279 N307 E108 Q144 D148 F273 N301
BS02 NAP A G188 T189 P191 I192 N211 R212 R213 T254 F277 G278 F279 V306 K354 G182 T183 P185 I186 N205 R206 R207 T248 F271 G272 F273 V300 K348
BS03 ZN A C39 H66 E67 C39 H60 E61
BS04 ZN A C93 C96 C99 C107 C87 C90 C93 C101
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005534 galactose binding
GO:0005536 D-glucose binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019151 galactose 1-dehydrogenase activity
GO:0033222 xylose binding
GO:0046872 metal ion binding
GO:0047640 aldose 1-dehydrogenase activity
GO:0047910 galactose 1-dehydrogenase (NADP+) activity
GO:0047934 glucose 1-dehydrogenase (NAD+) activity
GO:0047935 glucose 1-dehydrogenase (NADP+) activity
GO:0047936 glucose 1-dehydrogenase [NAD(P)+] activity
GO:0070401 NADP+ binding
GO:0070403 NAD+ binding
Biological Process
GO:0019595 non-phosphorylated glucose catabolic process
GO:0033498 galactose catabolic process via D-galactonate
GO:0051262 protein tetramerization

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Molecular Function
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Biological Process
External links
PDB RCSB:2cdb, PDBe:2cdb, PDBj:2cdb
PDBsum2cdb
PubMed16556607
UniProtO93715|GLCDH_SACSO Glucose 1-dehydrogenase (Gene Name=gdh)

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