Structure of PDB 2cbl Chain A

Receptor sequence
>2cblA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLR
TILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQ
PRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGE
KTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR
LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLS
CTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQN
PDLTG
3D structure
PDB2cbl Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S80 P81 Y274 R294 S296 C297 T298 Y307 Q316 T317 I318 P319 F336 Y337 S34 P35 Y228 R248 S250 C251 T252 Y261 Q270 T271 I272 P273 F290 Y291
BS02 CA A D229 T231 N233 Y235 E240 D183 T185 N187 Y189 E194
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:2cbl, PDBe:2cbl, PDBj:2cbl
PDBsum2cbl
PubMed10078535
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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