Structure of PDB 2cbf Chain A

Receptor sequence
>2cbfA (length=234) Species: 1404 (Priestia megaterium) [Search protein sequence]
GSHMKLYIIGAGPGDPDLITVKGLKLLQQADVVLYADSLVSQDLIAKSKP
GAEVLKTAGMHLEEMVGTMLDRMREGKMVVRVHTGDPAMYGAIMEQMVLL
KREGVDIEIVPGVTSVFAAAAAAEAELTIPDLTQTVILTRAEGRTPVPEF
EKLTDLAKHKCTIALFLSSTLTKKVMKEFINAGWSEDTPVVVVYKATWPD
EKIVRTTVKDLDDAMRTNGIRKQAMILAGWALDP
3D structure
PDB2cbf The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase.
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D54 L184
Catalytic site (residue number reindexed from 1) D37 L167
Enzyme Commision number 2.1.1.271: cobalt-precorrin-4 methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A T101 G102 D103 T131 S132 F183 L184 A213 Q240 A241 M242 T84 G85 D86 T114 S115 F166 L167 A196 Q223 A224 M225
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0046026 precorrin-4 C11-methyltransferase activity
Biological Process
GO:0009236 cobalamin biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2cbf, PDBe:2cbf, PDBj:2cbf
PDBsum2cbf
PubMed9665173
UniProtO87696|CBIF_PRIMG Cobalt-precorrin-4 C(11)-methyltransferase (Gene Name=cbiF)

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