Structure of PDB 2c7g Chain A

Receptor sequence

>2c7gA (length=453) Species: 1773 (Mycobacterium tuberculosis)

RPYYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPTPWGLVRS
GVAPDQPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELSERYDAVI
YAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPDLSGARAV
VIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEVVIVGRRG
PLQAAFTTLELRELADLDGVDVVIDPAELDGITDEDAAAVGKVCKQNIKV
LRGYADREPRPGHRRMVFRFLTSPIEIKGKRKVERIVLGRNELVSDGSGR
VAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQSGTIPNVGGRINGS
PNEYVVGWIKRGPTGVIGTNKKDAQDTVDTLIKNLGNAKEGAECKSFDHA
DQVADWLAARQPKLVTSAHWQVIDAFERAAGEPHGRPRVKLASLAELLRI
GLG

3D structure

• PDB: 2c7g Role of the His57-Glu214 Ionic Couple Located in the Active Site of Mycobacterium Tuberculosis Fpra.
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q57 D161 I368 G369
• Catalytic site (residue number reindexed from 1): Q56 D160 I367 G368
• Enzyme Commision number: 1.18.1.2: ferredoxin--NADP(+) reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G10 P13 S14 E40 M41 G47 L48 G52 V53 I60 V84 A103 V104 Q107 V158 Y324 G358 W359 G366 V367 I368 N371	G9 P12 S13 E39 M40 G46 L47 G51 V52 I59 V83 A102 V103 Q106 V157 Y323 G357 W358 G365 V366 I367 N370
BS02	ODP	A	R110 N155 G156 N157 V158 R199 R200 E211 V322 W359 P364 T365 G366	R109 N154 G155 N156 V157 R198 R199 E210 V321 W358 P363 T364 G365	MOAD: Kd=16uM

Gene Ontology

Molecular Function

• GO:0004324 ferredoxin-NADP+ reductase activity
• GO:0008860 ferredoxin-NAD+ reductase activity
• GO:0016491 oxidoreductase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0070401 NADP+ binding

Cellular Component

• GO:0009274 peptidoglycan-based cell wall

External links

• PDB: RCSB:2c7g, PDBe:2c7g, PDBj:2c7g
• PDBsum: 2c7g
• PubMed: 16846214
• UniProt: P9WIQ3|FPRA_MYCTU NADPH-ferredoxin reductase FprA (Gene Name=fprA)