Structure of PDB 2c49 Chain A

Receptor sequence
>2c49A (length=299) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
GKMEKITCVGHTALDYIFNVEKFPEPNTSIQIPSARKYYGGAAANTAVGI
KKLGVNSELLSCVGYDFKNSGYERYLKNLDINISKLYYSEEEETPKAWIF
TDKDNNQITFFLWGAAKHYKELNPPNFNTEIVHIATGDPEFNLKCAKKAY
GNNLVSFDPGQDLPQYSKEMLLEIIEHTNFLFMNKHEFERASNLLNFEID
DYLERVDALIVTKGSKGSVIYTKDKKIEIPCIKAGKVIDPTGAGDSYRAG
FLSAYVKGYDLEKCGLIGAATASFVVEAKGCQTNLPTWDKVVERLEKHR
3D structure
PDB2c49 Structure of Methanocaldococcus Jannaschii Nucleoside Kinase: An Archaeal Member of the Ribokinase Family.
ChainA
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G244 A245 G246 D247
Catalytic site (residue number reindexed from 1) G242 A243 G244 D245
Enzyme Commision number 2.7.1.213: cytidine kinase.
2.7.1.73: inosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN A D17 G42 G43 N47 A99 T111 F113 Q163 D164 D247 D15 G40 G41 N45 A97 T109 F111 Q161 D162 D245
BS02 ANP A Q109 N186 T214 G216 G219 C233 T243 A245 A274 Q107 N184 T212 G214 G217 C231 T241 A243 A272
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0008906 inosine kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019206 nucleoside kinase activity
GO:0043771 cytidine kinase activity
GO:0106366 guanosine kinase activity
Biological Process
GO:0009165 nucleotide biosynthetic process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2c49, PDBe:2c49, PDBj:2c49
PDBsum2c49
PubMed16929110
UniProtQ57849|NK_METJA Nucleoside kinase (Gene Name=MJ0406)

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