Structure of PDB 2c43 Chain A

Receptor sequence
>2c43A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFQGHMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDA
KAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDNPYPNFNFNI
SHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWET
IRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLSPLNLDI
GQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPTQRQFTILNFN
DLMSSAVPMTPEDPSFWDCFCFTEEIPIRN
3D structure
PDB2c43 Mechanism and substrate recognition of human holo ACP synthase.
ChainA
Resolution1.93 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.8.7: holo-[acyl-carrier-protein] synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A R57 R96 K99 G100 K101 P102 N118 I119 S120 H121 W187 E191 K195 G198 G200 L201 L205 R40 R79 K82 G83 K84 P85 N99 I100 S101 H102 W168 E172 K176 G179 G181 L182 L186
BS02 MG A D139 E191 D120 E172
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0008897 holo-[acyl-carrier-protein] synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009258 10-formyltetrahydrofolate catabolic process
GO:0015939 pantothenate metabolic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:0051604 protein maturation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2c43, PDBe:2c43, PDBj:2c43
PDBsum2c43
PubMed18022563
UniProtQ9NRN7|ADPPT_HUMAN L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (Gene Name=AASDHPPT)

[Back to BioLiP]