Structure of PDB 2c1g Chain A

Receptor sequence
>2c1gA (length=384) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
FEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVREL
INQDVKDKLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKIEET
EKTSLGKVHLTEDGQPFTLDQLFSDASKAKEQLIKELTSFWNFDYKDSQI
ILYEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKHQKVVALTFDDGPN
PATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWS
HPILSQLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLD
LSFIMWDVDSLDWKSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPR
VIEYLKNQGYTFVTIPEMLNTRLKAHELYYSRDE
3D structure
PDB2c1g Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.104: peptidoglycan-N-acetylglucosamine deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D276 H326 H330 D197 H247 H251
BS02 ZN A E144 E146 E99 E101
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
GO:0050119 N-acetylglucosamine deacetylase activity
GO:0060241 lysozyme inhibitor activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0042545 cell wall modification
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2c1g, PDBe:2c1g, PDBj:2c1g
PDBsum2c1g
PubMed16221761
UniProtQ8DP63|PGDA_STRR6 Peptidoglycan-N-acetylglucosamine deacetylase (Gene Name=pgdA)

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