Structure of PDB 2c0t Chain A

Receptor sequence
>2c0tA (length=428) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGS
YSLSVRDYDPRQGDTVKHYKIRFYISPRSTFSTLQELVDHYKKGNDGLCQ
KLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT
KVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEF
MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAA
NILVSASLVCKIADFGLARVIPIKWTAPEAINFGSFTIKSDVWSFGILLM
EIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRP
EERPTFEYIQSVLDDFYTATESQYEEIP
3D structure
PDB2c0t Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D360 R362 A364 N365 D378
Catalytic site (residue number reindexed from 1) D296 R298 A300 N301 D314
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L3G A L247 V255 A267 V268 K269 F281 T312 F314 M315 D322 L367 D378 F379 L183 V191 A203 V204 K205 F217 T248 F250 M251 D258 L303 D314 F315
BS02 CA A E498 Y501 E421 Y424
BS03 CA A N365 D378 N301 D314
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2c0t, PDBe:2c0t, PDBj:2c0t
PDBsum2c0t
PubMed16216497
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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