Structure of PDB 2c0c Chain A

Receptor sequence
>2c0cA (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
GVDLGTENLYFQSMMQKLVVTRLSPNFREAVTLSRDCPVPLPGDGDLLVR
NRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVALGLSASARYTVG
QAVAYMAPGSFAEYTVVPASIATPVPSVKPEYLTLLVSGTTAYISLKELG
GLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSSDEKSAFLKSLGC
DRPINYKTEPVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIV
IGFISGYQTPTGLSPVKAGTLPAKLLKKSASVQGFFLNHYLSKYQAAMSH
LLEMCVSGDLVCEVDLGDLSPEGRFTGLESIFRAVNYMYMGKNTGKIVVE
LPH
3D structure
PDB2c0c The Structure of Mgc45594 Gene Product
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.48: 15-oxoprostaglandin 13-reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A A67 T150 G174 G175 T176 S196 K200 Y215 S238 I260 I263 S264 Y266 L296 M347 G350 N352 A58 T141 G165 G166 T167 S187 K191 Y206 S229 I251 I254 S255 Y257 L287 M338 G341 N343
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0047522 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008150 biological_process
GO:0045599 negative regulation of fat cell differentiation
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2c0c, PDBe:2c0c, PDBj:2c0c
PDBsum2c0c
PubMed
UniProtQ8N4Q0|PTGR3_HUMAN Prostaglandin reductase 3 (Gene Name=PTGR3)

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