Structure of PDB 2bzg Chain A

Receptor sequence
>2bzgA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
EVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVF
FPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIP
GTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCY
ADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRC
LEKVDAFEERHKSWGIDCLFEKLYLLTEK
3D structure
PDB2bzg Structural Basis of Allele Variation of Human Thiopurine-S-Methyltransferase.
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.67: thiopurine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L26 W29 W33 F40 L69 C70 E90 I91 S134 I135 R152 G153 L10 W13 W17 F24 L53 C54 E74 I75 S118 I119 R136 G137
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008119 thiopurine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006805 xenobiotic metabolic process
GO:0032259 methylation
GO:0042178 xenobiotic catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2bzg, PDBe:2bzg, PDBj:2bzg
PDBsum2bzg
PubMed17243178
UniProtP51580|TPMT_HUMAN Thiopurine S-methyltransferase (Gene Name=TPMT)

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