Structure of PDB 2bxs Chain A

Receptor sequence
>2bxsA (length=490) Species: 9606 (Homo sapiens) [Search protein sequence]
HMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVD
YVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGW
NPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICW
TKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQE
RKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYEC
KYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWK
KKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHK
EIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIM
TQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKV
TEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIG
3D structure
PDB2bxs Three-Dimensional Structure of Human Monoamine Oxidase a (Mao A): Relation to the Structures of Rat Mao a and Human Mao B
ChainA
Resolution3.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G71 R206 K305
Catalytic site (residue number reindexed from 1) G60 R190 K289
Enzyme Commision number 1.4.3.21: primary-amine oxidase.
1.4.3.4: monoamine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I19 G22 S24 E43 G50 R51 G66 G67 A68 Y69 P243 V244 I273 W397 Y402 C406 Y407 T435 G443 Y444 M445 I8 G11 S13 E32 G39 R40 G55 G56 A57 Y58 P227 V228 I257 W381 Y386 C390 Y391 T419 G427 Y428 M429
BS02 MLG A E216 I335 L337 F352 Y407 E200 I319 L321 F336 Y391 BindingDB: IC50=4.5nM,Ki=12nM
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008131 primary methylamine oxidase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052595 aliphatic amine oxidase activity
GO:0097621 monoamine oxidase activity
Biological Process
GO:0006576 biogenic amine metabolic process
GO:0006584 catecholamine metabolic process
GO:0009967 positive regulation of signal transduction
GO:0042420 dopamine catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2bxs, PDBe:2bxs, PDBj:2bxs
PDBsum2bxs
PubMed16129825
UniProtP21397|AOFA_HUMAN Amine oxidase [flavin-containing] A (Gene Name=MAOA)

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