Structure of PDB 2bw7 Chain A

Receptor sequence
>2bw7A (length=198) Species: 118562 (Arthrospira platensis) [Search protein sequence]
SHMRPEPRLITILFSDIVGFTRMSNALQSQGVAELLNEYLGEMTRAVFEN
QGTVDKFVGDAIMALYGAPEEMSPSEQVRRAIATARQMLVALEKLNQGWQ
ERGLVGRNEVPPVRFRCGIHQGMAVVGLFGSQERSDFTAIGPSVNIAARL
QEATAPNSIMVSAMVAQYVPDEEIIKREFLELKGIDEPVMTCVINPNM
3D structure
PDB2bw7 A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APC A D1017 I1018 V1019 G1020 F1021 T1022 G1060 D1061 R1117 D16 I17 V18 G19 F20 T21 G59 D60 R116
BS02 CA A D1017 I1018 D1061 D16 I17 D60
BS03 ECS A F1015 D1017 N1146 A1149 R1150 E1153 F14 D16 N145 A148 R149 E152 MOAD: ic50~2uM
PDBbind-CN: -logKd/Ki=5.70,IC50=2uM
BS04 APC A M1064 A1140 I1141 G1142 V1145 N1146 M63 A139 I140 G141 V144 N145
Gene Ontology
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:2bw7, PDBe:2bw7, PDBj:2bw7
PDBsum2bw7
PubMed16002394
UniProtO32393

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