Structure of PDB 2bvw Chain A

Receptor sequence
>2bvwA (length=361) Species: 34413 (Humicola insolens) [Search protein sequence]
NGNPFEGVQLWANNYYRSEVHTLAIPQITDPALRAAASAVAEVPSFQWLD
RNVTVDTLLVQTLSEIREANQAGANPQYAAQIVVYDLPDRDCAAAASNGE
WAIANNGVNNYKAYINRIREILISFSDVRTILVIEPDSLANMVTNMNVPK
CSGAASTYRELTIYALKQLDLPHVAMYMDAGHAGWLGWPANIQPAAELFA
KIYEDAGKPRAVRGLATNVANYNAWSVSSPPPYTSPNPNYDEKHYIEAFR
PLLEARGFPAQFIVDQGRSGKQPTGQKEWGHWCNAIGTGFGMRPTANTGH
QYVDAFVWVKPGGECDGTSDTTAARYDYHCGLEDALKPAPEAGQWFNEYF
IQLLRNANPPF
3D structure
PDB2bvw Structural changes of the active site tunnel of Humicola insolens cellobiohydrolase, Cel6A, upon oligosaccharide binding.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y174 R179 D180 S186 D226 D405
Catalytic site (residue number reindexed from 1) Y85 R90 D91 S97 D137 D316
Enzyme Commision number 3.2.1.91: cellulose 1,4-beta-cellobiosidase (non-reducing end).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A T233 G273 W274 T144 G184 W185
BS02 BGC A N234 H271 N145 H182
BS03 BGC A D180 D226 W371 D91 D137 W282
BS04 BGC A W137 D139 S186 K399 P400 E403 W48 D50 S97 K310 P311 E314
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0030245 cellulose catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2bvw, PDBe:2bvw, PDBj:2bvw
PDBsum2bvw
PubMed10413461
UniProtQ9C1S9|GUX6_HUMIN Exoglucanase-6A (Gene Name=cel6A)

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