Structure of PDB 2bvn Chain A

Receptor sequence
>2bvnA (length=372) Species: 511693 (Escherichia coli BL21) [Search protein sequence]
KPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGEKARGITINTSHVEYDT
PTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILL
GRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVR
GSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSIS
GRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAG
ENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTP
FFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDG
LRFAIREGGRTVGAGVVAKVLS
3D structure
PDB2bvn Enacyloxin Iia Pinpoints a Binding Pocket of Elongation Factor TU for Development of Novel Antibiotics.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D21 K24 T25 T61 H84
Catalytic site (residue number reindexed from 1) D13 K16 T17 T40 H63
Enzyme Commision number 3.6.1.48: Transferred entry: 3.6.5.3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A D21 G23 K24 T25 T26 G83 N135 K136 D138 M139 S173 L175 D13 G15 K16 T17 T18 G62 N114 K115 D117 M118 S152 L154
BS02 ENX A R123 Q124 V125 Q159 Y160 L311 K313 D314 E315 Y331 R333 R373 F374 A375 R102 Q103 V104 Q138 Y139 L290 K292 D293 E294 Y310 R312 R352 F353 A354
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032045 guanyl-nucleotide exchange factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2bvn, PDBe:2bvn, PDBj:2bvn
PDBsum2bvn
PubMed16257965
UniProtP0CE48|EFTU2_ECOLI Elongation factor Tu 2 (Gene Name=tufB)

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