Structure of PDB 2bs2 Chain A

Receptor sequence

>2bs2A (length=655) Species: 844 (Wolinella succinogenes)

MKVQYCDSLVIGGGLAGLRAAVATQQKGLSTIVLSLIPVKRSHSAAAQGG
MQASLGNSKMSDGDNEDLHFMDTVKGSDWGCDQKVARMFVNTAPKAIREL
AAWGVPWTRIHKGDRMAIINAQKTTITEEDFRHGLIHSRDFGGTKKWRTC
YTADATGHTMLFAVANECLKLGVSIQDRKEAIALIHQDGKCYGAVVRDLV
TGDIIAYVAKGTLIATGGYGRIYKNTTNAVVCEGTGTAIALETGIAQLGN
MEAVQFHPTPLFPSGILLTEGCRGDGGILRDVDGHRFMPDYEPEKKELAS
RDVVSRRMIEHIRKGKGVQSPYGQHLWLDISILGRKHIETNLRDVQEICE
YFAGIDPAEKWAPVLPMQHYSMGGIRTDYRGEAKLKGLFSAGEAACWDMH
GFNRLGGNSVSEAVVAGMIVGEYFAEHCANTQVDLETKTLEKFVKGQEAY
MKSLVESKGTEDVFKIKNRMKDVMDDNVGIFRDGPHLEKAVKELEELYKK
SKNVGIKNKRLHANPELEEAYRVPMMLKVALCVAKGALDRTESRGAHNRE
DYPKRDDINWLNRTLASWPNPEQTLPTLEYEALDVNEMEIAPGYRGYGAK
GNYIENPLSVKRQEEIDKIQSELEAAGKDRHAIQEALMPYELPAKYKARN
ERLGD

3D structure

• PDB: 2bs2 Evidence for Transmembrane Proton Transfer in a Dihaem-Containing Membrane Protein Complex.
• Chain: A
• Resolution: 1.78 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): F141 Q255 H257 L267 E270 R273 R301 H369 Y370 R404
• Catalytic site (residue number reindexed from 1): F141 Q255 H257 L267 E270 R273 R301 H369 Y370 R404
• Enzyme Commision number: 1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G12 G13 G14 A16 S35 L36 S42 H43 S44 A47 G49 G50 A181 A215 T216 G217 L267 H369 Y370 E393 R404 G407 S409 V410	G12 G13 G14 A16 S35 L36 S42 H43 S44 A47 G49 G50 A181 A215 T216 G217 L267 H369 Y370 E393 R404 G407 S409 V410
BS02	FUM	A	F141 H257 L267 T269 E270 H369 R404	F141 H257 L267 T269 E270 H369 R404

Gene Ontology

Molecular Function

• GO:0000104 succinate dehydrogenase activity
• GO:0008177 succinate dehydrogenase (quinone) activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0009061 anaerobic respiration
• GO:0022900 electron transport chain

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:2bs2, PDBe:2bs2, PDBj:2bs2
• PDBsum: 2bs2
• PubMed: 17024183
• UniProt: P17412|FRDA_WOLSU Fumarate reductase flavoprotein subunit (Gene Name=frdA)