Structure of PDB 2bqz Chain A

Receptor sequence

>2bqzA (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]

RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDF
VVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETN
RLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSK
ASIEAHPWLKH

3D structure

PDB

2bqz Specificity and Mechanism of the Histone Methyltransferase Pr-Set7

Chain

Resolution

1.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y245 E259 A263 D265 P266 T268 C270 M272 Y273 Y274 T307 K308 Y336 G337 D338 S343 H347 W349	Y54 E68 A72 D74 P75 T77 C79 M81 Y82 Y83 T116 K117 Y145 G146 D147 S152 H156 W158
BS02	SAH	A	G225 K226 R228 Y271 L296 N298 H299 Y336 W349	G34 K35 R37 Y80 L105 N107 H108 Y145 W158

Gene Ontology

	Molecular Function
GO:0042799	histone H4K20 methyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:2bqz, PDBe:2bqz, PDBj:2bqz
PDBsum	2bqz
PubMed	15933069
UniProt	Q9NQR1\|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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